Week 14: Settling at 10mg
Two injections into the new dose, the titration noise fades. Appetite suppression stabilizes at a deeper level than 7.5mg, and the weekly loss trend resumes its line.
The pattern that emerges in week 14 is usually a deeper version of what you had on 7.5mg. Meals end sooner. The pull toward seconds is weaker. The window between hunger cues stretches longer. None of this is new — it is just more pronounced.
For users whose week 12 loss had begun to slow, the second dose at 10mg often restores the trend. For users who were still losing comfortably on 7.5mg, the bigger dose tends to nudge that pace up by a fraction. SURMOUNT-1 data suggest the 10mg arm continued to separate from the 5mg arm through this stretch.
Appetite Suppression
Near-total at this point for most users. Some report having to set meal reminders to avoid skipping eating entirely.
Typical second-week-at-dose loss. Cumulative loss by end of week 14 commonly lands at 10 to 14 percent of starting body weight.
Week 14 Timeline
The Week 14 Timeline
Day 92 (Injection 14)
Second 10mg Dose
Injection routine is unchanged. With tissue levels already at the new plateau, the post-injection window is typically smoother than week 13.
Days 94-96
Pattern Locks In
The new appetite baseline is the working baseline. Meal sizes, snack timing, and food choices stop feeling like a fight and start feeling automatic.
Day 98
Mid-Cycle Check
End-of-week weigh-in usually shows a clean number — the titration bump has settled and the dose is doing its work without noise.
Navigating Symptoms
If you are losing more than 3 pounds a week for several weeks in a row, slow it down deliberately — more protein, more calories, more strength work. Rapid loss past month 3 increases lean-mass loss disproportionately.
Protein and resistance training move from optional to mandatory at this stage. With deep appetite suppression, it is genuinely possible to undereat at a level your body will respond to by shedding muscle alongside fat. Aim for 1.2 to 1.6g of protein per kilogram of body weight daily and two structured strength sessions a week.
What Users Report
“Week 14 was the calmest week I have had on this medication. No nausea, no thinking about food, scale moved 2 pounds. This is what people meant by 'the easy part'.”
— Priya N.
“I have to set alarms to eat lunch. Sounds dramatic, but at 10mg I genuinely forget. Lifting four days a week keeps the loss from feeling too fast.”
— Toby R.
Looking ahead
Week 15 is mid-cycle on 10mg — the moment to watch for the first hint of a true plateau on the new dose. Continue to the week 15 guide for what to look for and how to read the scale data.