Week 18: First Week on the Target Dose
Second injection at 2.4mg. The brief titration flare from week 17 typically fades, side effects settle, and the target dose becomes the new normal — quieter appetite, steadier weeks, the start of long-term work.
Week 18 is the second injection at 2.4mg and the first full week where the body has been running on the target dose throughout. The adjustment effects from week 17 — brief nausea, lower energy, deeper appetite drop — have usually faded, and what remains is the steady picture of life at the top of the standard schedule.
The change between 1.7mg and 2.4mg is usually less dramatic than the change between 1.0mg and 1.7mg. Many users describe it as more of the same suppression, slightly more reliable, rather than a step into new territory. That can be a relief or a mild disappointment depending on what you expected.
Appetite Suppression
Strong, dependable suppression at the target dose. Spontaneous hunger is rare for most users; meals are mostly schedule-driven.
Loss tends to continue at a steady pace through the first month at 2.4mg, though weeks of slower change become more common.
The Week 18 Timeline
The Week 18 Timeline
Day 120 (Injection 18)
Second 2.4mg Dose
The second shot at the target dose. Most users find this one easier than week 17 — adjustment effects are typically much milder.
Days 122-124
Quiet Baseline
Appetite stays low and predictable. The target dose feels normal rather than novel.
Day 126
Maintenance Mindset
End of week one at 2.4mg. The titration phase is officially behind you — the long work of maintenance and habit consolidation begins.
Navigating Symptoms
Constipation and dry mouth are the most common lingering effects at the target dose. Daily fiber, water, and movement tend to address both more reliably than reactive fixes.
The work at the target dose is consistency. The medication will keep doing its part — that is what 2.4mg is designed for. The variable you control is everything around it: protein, fluids, sleep, movement, and the day-to-day decisions about what to put on the plate when nothing sounds appetizing. The dose makes those decisions lighter; it does not make them.
It is also a good week to recalibrate expectations on weight loss pace. Trial data shows mean weight loss continuing throughout the first year but slowing meaningfully — the curve flattens as you go. A week of slower loss is not a stall; it is the shape of the response. Watching the trend over four weeks rather than reading individual weigh-ins keeps the picture honest.
What Users Report
“Second week at 2.4mg felt easy. The dose just feels like my baseline now. I'm eating less without thinking about it and the side effects are quiet.”
— Yara K.
“Honestly, the jump from 1.7 to 2.4 felt smaller than I expected. The hunger reduction was already strong at 1.7mg, and this just made it a bit more reliable.”
— Owen P.
Looking ahead
Week 19 is the middle of the first month at 2.4mg. Most users are fully settled by then, and the picture of life at the target dose becomes clear. The next few weeks are about identifying the routine that works and protecting it.