All GLP-1 Journey Guides
235 hand-edited guides organized by topic, category, and medication. New guides go live every day.
scheduleTherapeutic phase (Weeks 13-24) · 24 guides
Settling into higher doses through month six. Habits consolidate.
Week 13 on Semaglutide: Titrating Toward 1.7mg
Week 13 brings the jump from 1.0mg to 1.7mg semaglutide. Side effects can flare briefly. Here is what to expect and how to handle the new dose.
Read guidearrow_forwardWeek 13 on Tirzepatide: Stepping Up to 10mg
Week 13 on tirzepatide is the first injection at 10mg. Expect a brief return of GI side effects, a deeper appetite quiet, and a higher weekly loss range.
Read guidearrow_forwardWeek 14 on Semaglutide: Settling at 1.7mg
Week 14 is the second injection at 1.7mg. The titration shock typically fades and the new dose becomes the new baseline. Here is what to expect.
Read guidearrow_forwardWeek 14 on Tirzepatide: Settling at 10mg
Week 14 on tirzepatide is the first full settled week at 10mg. Side effects ease, appetite suppression stabilizes, and the loss trend resumes.
Read guidearrow_forwardWeek 15 on Semaglutide: Mid-Titration Steady
Week 15 is the midpoint of the 1.7mg block. Side effects are usually quiet, weight loss is steady, and the focus shifts to habits over heroics.
Read guidearrow_forwardWeek 15 on Tirzepatide: Mid-10mg Plateau Watch
Week 15 on tirzepatide is the mid-cycle mark at 10mg. The honeymoon ends for some, the trend continues for others — here is how to read the scale this week.
Read guidearrow_forwardWeek 16 on Semaglutide: Closing Out 1.7mg
Week 16 is the last week at 1.7mg before the final titration to 2.4mg. Here is how to review progress and prepare for the target dose.
Read guidearrow_forwardWeek 16 on Tirzepatide: Closing Out 10mg
Week 16 on tirzepatide is the final dose at 10mg before the next titration window. Time to review the four-week trend and prepare the 12.5mg conversation.
Read guidearrow_forwardWeek 17 on Semaglutide: Stepping Up to 2.4mg
Week 17 brings the final titration to 2.4mg, the target Wegovy dose. Side effects can briefly return. Here is what to expect at the top of the schedule.
Read guidearrow_forwardWeek 17 on Tirzepatide: Stepping Up to 12.5mg
Week 17 on tirzepatide is the first injection at 12.5mg. Side effects can return briefly, appetite suppression deepens, and the loss curve often reaccelerates.
Read guidearrow_forwardWeek 18 on Semaglutide: First Week on the Target Dose
Week 18 is the second injection at 2.4mg. The titration shock fades, the target dose becomes the new baseline, and maintenance work begins.
Read guidearrow_forwardWeek 18 on Tirzepatide: Settling Into 12.5mg
Week 18 on tirzepatide is the first settled week at 12.5mg. The titration bump fades, appetite stays near-silent, and the trend continues at a sustainable pace.
Read guidearrow_forwardWeek 19 on Semaglutide: Settling Into 2.4mg
Week 19 is the third week at 2.4mg. The target dose feels routine, side effects are usually quiet, and the focus shifts to sustainable habits.
Read guidearrow_forwardWeek 19 on Tirzepatide: Mid-12.5mg
Week 19 on tirzepatide is the mid-cycle mark at 12.5mg. The dose is at full steady state and the loss trend, with or without a flat week, is the focus.
Read guidearrow_forwardWeek 20 on Semaglutide: Steady at Target
Week 20 closes the first full month at 2.4mg semaglutide. The dose is settled, habits are consolidating, and the long maintenance phase begins.
Read guidearrow_forwardWeek 20 on Tirzepatide: Closing Out 12.5mg
Week 20 on tirzepatide is the final dose at 12.5mg before the 15mg window opens. Time to weigh maximum-dose benefits against staying where you are.
Read guidearrow_forwardWeek 21 on Semaglutide: Five Months In
Week 21 marks five months on semaglutide. The dose is settled, habits are deepening, and the long maintenance phase reveals its rhythm.
Read guidearrow_forwardWeek 21 on Tirzepatide: Stepping Up to 15mg
Week 21 on tirzepatide is the first injection at the 15mg maximum dose. Side effects can return, appetite goes near-silent, and the loss curve gets its final boost.
Read guidearrow_forwardWeek 22 on Semaglutide: Building Habits at Target Dose
Week 22 is deep in the 2.4mg maintenance phase. Habits are doing more of the work than novelty. Here is what to focus on at this stage.
Read guidearrow_forwardWeek 22 on Tirzepatide: First Full Week at 15mg
Week 22 on tirzepatide is the first settled week at the maximum 15mg dose. Titration noise is gone, appetite is near-total, and the trend continues at a sustainable slope.
Read guidearrow_forwardWeek 23 on Semaglutide: Approaching the Half-Year Mark
Week 23 is the last week before the six-month milestone on semaglutide. A natural time to prepare data and questions for the half-year review.
Read guidearrow_forwardWeek 23 on Tirzepatide: Approaching the Half-Year Mark
Week 23 on tirzepatide is the third dose at 15mg and the last week before the six-month milestone. Time to prepare the data and read the half-year picture.
Read guidearrow_forwardWeek 24 on Semaglutide: The Six-Month Milestone
Week 24 marks six months on semaglutide. STEP trial data shows ~10% mean body-weight loss at this point. Here is how to review and plan ahead.
Read guidearrow_forwardWeek 24 on Tirzepatide: The Six-Month Milestone
Week 24 on tirzepatide marks six months. SURMOUNT-1 puts cumulative loss near 20% on 15mg at this point. Time to review the half-year and plan ahead.
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