All GLP-1 Journey Guides
110 hand-edited guides organized by topic, category, and medication. New guides go live every day.
Journey · 24 guides
Week-by-week guides for both medications
play_arrowStarting out (Weeks 1-4) (6)
The first month — first injection, early appetite changes, initial side effects.
Week 1 on Semaglutide: What to Expect After Your First Injection
Your first week on semaglutide at 0.25mg — what the starter dose does, common day-by-day sensations, and how to set yourself up for a steady start.
Read guidearrow_forwardWeek 1 on Tirzepatide: Starting at 2.5mg
What to expect during your first week on tirzepatide 2.5mg — the starter dose, early appetite changes, and how to settle in.
Read guidearrow_forwardWeek 2 on Semaglutide: The Adjustment Phase
Week 2 of semaglutide at 0.25mg — the medication starts to build up, side effects can peak, and food noise begins to fade for many people.
Read guidearrow_forwardWeek 2 on Tirzepatide: Settling Into the Starter Dose
Week 2 of tirzepatide at 2.5mg — what changes after your second injection, common side effects, and how to read your body's signals.
Read guidearrow_forwardWeek 4 on Semaglutide: Closing Out the Starter Dose
Week 4 of semaglutide closes out the 0.25mg starter dose — what to expect, how to tell if you are ready to titrate up, and how to prepare for 0.5mg.
Read guidearrow_forwardWeek 4 on Tirzepatide: Last Week Before the First Step Up
Week 4 on tirzepatide — the final week at 2.5mg before titrating to 5mg. What to expect and how to prepare for the dose increase.
Read guidearrow_forwardtrending_upTitration phase (Weeks 5-12) (8)
Stepping up doses through the first three months toward your therapeutic dose.
Week 10 on Semaglutide: Settling into 1.0mg
Week 10 of semaglutide is when 1.0mg starts to feel normal. Side effects ease, appetite suppression holds, and a clearer weight trend often emerges.
Read guidearrow_forwardWeek 10 on Tirzepatide: Settling into 7.5mg
Week 10 is your second week at 7.5mg tirzepatide. Side effects typically ease and appetite suppression deepens. Here is what to track.
Read guidearrow_forwardWeek 11 on Semaglutide: Hitting Your Rhythm
Week 11 is the steady middle of the 1.0mg phase. Appetite suppression is reliable, side effects are usually minimal, and non-scale wins start adding up.
Read guidearrow_forwardWeek 11 on Tirzepatide: Adjusting to the Therapeutic Dose
Week 11 on tirzepatide: 7.5mg is now your steady-state dose. Here is how appetite, energy, weight, and side effects typically behave at this milestone.
Read guidearrow_forwardWeek 12 on Semaglutide: The First Big Milestone
Week 12 marks three months on semaglutide. Average cumulative loss approaches 6% body weight per STEP trial data. Here's how to review and plan ahead.
Read guidearrow_forwardWeek 12 on Tirzepatide: The First Big Milestone
Week 12 on tirzepatide marks three months and your first major checkpoint. Review weight, side effects, lab work, and the decision about the next dose.
Read guidearrow_forwardWeek 8 on Semaglutide: Final Week at 0.5mg
Week 8 is your last week at 0.5mg before titration to 1.0mg. Here's how to prepare, what side effects to expect, and how to talk to your prescriber.
Read guidearrow_forwardWeek 8 on Tirzepatide: Last Week at 5mg
Week 8 closes the 5mg phase of tirzepatide. Review side effects, weight trends, and how to prepare for the standard titration to 7.5mg.
Read guidearrow_forwardscheduleTherapeutic phase (Weeks 13-24) (2)
Settling into higher doses through month six. Habits consolidate.
Week 13 on Semaglutide: Titrating Toward 1.7mg
Week 13 brings the jump from 1.0mg to 1.7mg semaglutide. Side effects can flare briefly. Here is what to expect and how to handle the new dose.
Read guidearrow_forwardWeek 13 on Tirzepatide: Stepping Up to 10mg
Week 13 on tirzepatide is the first injection at 10mg. Expect a brief return of GI side effects, a deeper appetite quiet, and a higher weekly loss range.
Read guidearrow_forwardeventMonth markers (Month 3 - 12) (8)
Three-month checkpoints from month three through year one.
Month 12 on Semaglutide: One Year In
One year on semaglutide. STEP 1 reports ~14.9% mean weight loss at 68 weeks, close to plateau. Time to review labs, dose, and the long-term plan.
Read guidearrow_forwardMonth 12 on Tirzepatide: One Year of Treatment Reviewed
One year on tirzepatide. SURMOUNT-1 reports up to ~20.9% mean weight loss at 72 weeks on 15mg. Review labs, dose, lean mass, and the long-term plan.
Read guidearrow_forwardMonth 3 on Semaglutide: What 12 Weeks of Treatment Looks Like
Month 3 on semaglutide is the standard checkpoint. STEP trial data shows ~6% cumulative loss, the 1.0mg dose is settling, and the next titration is on deck.
Read guidearrow_forwardMonth 3 on Tirzepatide: The First Real Milestone
Month 3 on tirzepatide is the standard checkpoint. SURMOUNT-1 shows ~10% cumulative loss by 12 weeks on the higher dose. Time to review and plan.
Read guidearrow_forwardMonth 6 on Semaglutide: The Halfway Mark of a Year
Month 6 on semaglutide marks the halfway point. STEP 1 shows ~10% cumulative loss, the dose is approaching maintenance, and the trajectory is set.
Read guidearrow_forwardMonth 6 on Tirzepatide: Halfway Through the First Year
Month 6 on tirzepatide marks halfway. SURMOUNT-1 shows ~15% cumulative loss on the higher dose. Dose at 10mg, side effects routine, plateaus possible.
Read guidearrow_forwardMonth 9 on Semaglutide: Approaching Maintenance
Month 9 on semaglutide is where the curve begins to flatten. STEP 1 data shows ~13% cumulative loss, and the conversation shifts toward maintenance.
Read guidearrow_forwardMonth 9 on Tirzepatide: Where the Curve Levels Out
Month 9 on tirzepatide is where the steep loss curve begins to flatten. SURMOUNT-1 shows ~18% cumulative loss on the higher dose at this stage.
Read guidearrow_forward