All GLP-1 Journey Guides
235 hand-edited guides organized by topic, category, and medication. New guides go live every day.
Journey · 56 guides
Week-by-week guides for both medications
play_arrowStarting out (Weeks 1-4) (8)
The first month — first injection, early appetite changes, initial side effects.
Week 1 on Semaglutide: What to Expect After Your First Injection
Your first week on semaglutide at 0.25mg — what the starter dose does, common day-by-day sensations, and how to set yourself up for a steady start.
Read guidearrow_forwardWeek 1 on Tirzepatide: Starting at 2.5mg
What to expect during your first week on tirzepatide 2.5mg — the starter dose, early appetite changes, and how to settle in.
Read guidearrow_forwardWeek 2 on Semaglutide: The Adjustment Phase
Week 2 of semaglutide at 0.25mg — the medication starts to build up, side effects can peak, and food noise begins to fade for many people.
Read guidearrow_forwardWeek 2 on Tirzepatide: Settling Into the Starter Dose
Week 2 of tirzepatide at 2.5mg — what changes after your second injection, common side effects, and how to read your body's signals.
Read guidearrow_forwardWeek 3 on Semaglutide: Finding Your Rhythm
What to expect in week 3 of semaglutide treatment — appetite suppression stabilizes, side effects ease, and the journey hits its rhythm.
Read guidearrow_forwardWeek 3 on Tirzepatide: Finding Your Rhythm at 2.5mg
Week 3 on tirzepatide 2.5mg — appetite suppression strengthens, side effects ease, and the starter phase finds its rhythm.
Read guidearrow_forwardWeek 4 on Semaglutide: Closing Out the Starter Dose
Week 4 of semaglutide closes out the 0.25mg starter dose — what to expect, how to tell if you are ready to titrate up, and how to prepare for 0.5mg.
Read guidearrow_forwardWeek 4 on Tirzepatide: Last Week Before the First Step Up
Week 4 on tirzepatide — the final week at 2.5mg before titrating to 5mg. What to expect and how to prepare for the dose increase.
Read guidearrow_forwardtrending_upTitration phase (Weeks 5-12) (16)
Stepping up doses through the first three months toward your therapeutic dose.
Week 10 on Semaglutide: Settling into 1.0mg
Week 10 of semaglutide is when 1.0mg starts to feel normal. Side effects ease, appetite suppression holds, and a clearer weight trend often emerges.
Read guidearrow_forwardWeek 10 on Tirzepatide: Settling into 7.5mg
Week 10 is your second week at 7.5mg tirzepatide. Side effects typically ease and appetite suppression deepens. Here is what to track.
Read guidearrow_forwardWeek 11 on Semaglutide: Hitting Your Rhythm
Week 11 is the steady middle of the 1.0mg phase. Appetite suppression is reliable, side effects are usually minimal, and non-scale wins start adding up.
Read guidearrow_forwardWeek 11 on Tirzepatide: Adjusting to the Therapeutic Dose
Week 11 on tirzepatide: 7.5mg is now your steady-state dose. Here is how appetite, energy, weight, and side effects typically behave at this milestone.
Read guidearrow_forwardWeek 12 on Semaglutide: The First Big Milestone
Week 12 marks three months on semaglutide. Average cumulative loss approaches 6% body weight per STEP trial data. Here's how to review and plan ahead.
Read guidearrow_forwardWeek 12 on Tirzepatide: The First Big Milestone
Week 12 on tirzepatide marks three months and your first major checkpoint. Review weight, side effects, lab work, and the decision about the next dose.
Read guidearrow_forwardWeek 5 on Semaglutide: First Dose Increase to 0.5mg
Week 5 is your first dose increase on semaglutide, from 0.25mg to 0.5mg — what changes, what side effects to watch for, and how to land softly on the new dose.
Read guidearrow_forwardWeek 5 on Tirzepatide: Titrating Up to 5mg
Week 5 on tirzepatide — your first dose increase to 5mg. What changes, what side effects to expect, and how to ride out the bump.
Read guidearrow_forwardWeek 6 on Semaglutide: Adjusting to 0.5mg
Week 6 on semaglutide is the settling week at 0.5mg — side effects from the dose increase usually fade, appetite suppression deepens, and progress becomes more visible.
Read guidearrow_forwardWeek 6 on Tirzepatide: Adjusting to 5mg
Week 6 on tirzepatide 5mg — the side-effect rebound fades and the new appetite baseline settles in. What to track and how to read your body.
Read guidearrow_forwardWeek 7 on Semaglutide: Halfway Through Acclimation
Week 7 of semaglutide marks the midpoint of the 0.5mg phase. Appetite suppression is steady, side effects have softened, and habits start to lock in.
Read guidearrow_forwardWeek 7 on Tirzepatide: Halfway Through 5mg
Week 7 marks the midpoint of your 5mg tirzepatide phase. Here is what to expect: steadier appetite control, weight loss patterns, and side effect trends.
Read guidearrow_forwardWeek 8 on Semaglutide: Final Week at 0.5mg
Week 8 is your last week at 0.5mg before titration to 1.0mg. Here's how to prepare, what side effects to expect, and how to talk to your prescriber.
Read guidearrow_forwardWeek 8 on Tirzepatide: Last Week at 5mg
Week 8 closes the 5mg phase of tirzepatide. Review side effects, weight trends, and how to prepare for the standard titration to 7.5mg.
Read guidearrow_forwardWeek 9 on Semaglutide: Stepping Up to 1.0mg
Week 9 is your first injection at 1.0mg semaglutide. Expect a mild side effect echo, stronger appetite suppression, and a new baseline forming.
Read guidearrow_forwardWeek 9 on Tirzepatide: Titrating to 7.5mg
Your first week on 7.5mg tirzepatide. What appetite changes, side effects, and weight trends to expect during this important step-up.
Read guidearrow_forwardscheduleTherapeutic phase (Weeks 13-24) (24)
Settling into higher doses through month six. Habits consolidate.
Week 13 on Semaglutide: Titrating Toward 1.7mg
Week 13 brings the jump from 1.0mg to 1.7mg semaglutide. Side effects can flare briefly. Here is what to expect and how to handle the new dose.
Read guidearrow_forwardWeek 13 on Tirzepatide: Stepping Up to 10mg
Week 13 on tirzepatide is the first injection at 10mg. Expect a brief return of GI side effects, a deeper appetite quiet, and a higher weekly loss range.
Read guidearrow_forwardWeek 14 on Semaglutide: Settling at 1.7mg
Week 14 is the second injection at 1.7mg. The titration shock typically fades and the new dose becomes the new baseline. Here is what to expect.
Read guidearrow_forwardWeek 14 on Tirzepatide: Settling at 10mg
Week 14 on tirzepatide is the first full settled week at 10mg. Side effects ease, appetite suppression stabilizes, and the loss trend resumes.
Read guidearrow_forwardWeek 15 on Semaglutide: Mid-Titration Steady
Week 15 is the midpoint of the 1.7mg block. Side effects are usually quiet, weight loss is steady, and the focus shifts to habits over heroics.
Read guidearrow_forwardWeek 15 on Tirzepatide: Mid-10mg Plateau Watch
Week 15 on tirzepatide is the mid-cycle mark at 10mg. The honeymoon ends for some, the trend continues for others — here is how to read the scale this week.
Read guidearrow_forwardWeek 16 on Semaglutide: Closing Out 1.7mg
Week 16 is the last week at 1.7mg before the final titration to 2.4mg. Here is how to review progress and prepare for the target dose.
Read guidearrow_forwardWeek 16 on Tirzepatide: Closing Out 10mg
Week 16 on tirzepatide is the final dose at 10mg before the next titration window. Time to review the four-week trend and prepare the 12.5mg conversation.
Read guidearrow_forwardWeek 17 on Semaglutide: Stepping Up to 2.4mg
Week 17 brings the final titration to 2.4mg, the target Wegovy dose. Side effects can briefly return. Here is what to expect at the top of the schedule.
Read guidearrow_forwardWeek 17 on Tirzepatide: Stepping Up to 12.5mg
Week 17 on tirzepatide is the first injection at 12.5mg. Side effects can return briefly, appetite suppression deepens, and the loss curve often reaccelerates.
Read guidearrow_forwardWeek 18 on Semaglutide: First Week on the Target Dose
Week 18 is the second injection at 2.4mg. The titration shock fades, the target dose becomes the new baseline, and maintenance work begins.
Read guidearrow_forwardWeek 18 on Tirzepatide: Settling Into 12.5mg
Week 18 on tirzepatide is the first settled week at 12.5mg. The titration bump fades, appetite stays near-silent, and the trend continues at a sustainable pace.
Read guidearrow_forwardWeek 19 on Semaglutide: Settling Into 2.4mg
Week 19 is the third week at 2.4mg. The target dose feels routine, side effects are usually quiet, and the focus shifts to sustainable habits.
Read guidearrow_forwardWeek 19 on Tirzepatide: Mid-12.5mg
Week 19 on tirzepatide is the mid-cycle mark at 12.5mg. The dose is at full steady state and the loss trend, with or without a flat week, is the focus.
Read guidearrow_forwardWeek 20 on Semaglutide: Steady at Target
Week 20 closes the first full month at 2.4mg semaglutide. The dose is settled, habits are consolidating, and the long maintenance phase begins.
Read guidearrow_forwardWeek 20 on Tirzepatide: Closing Out 12.5mg
Week 20 on tirzepatide is the final dose at 12.5mg before the 15mg window opens. Time to weigh maximum-dose benefits against staying where you are.
Read guidearrow_forwardWeek 21 on Semaglutide: Five Months In
Week 21 marks five months on semaglutide. The dose is settled, habits are deepening, and the long maintenance phase reveals its rhythm.
Read guidearrow_forwardWeek 21 on Tirzepatide: Stepping Up to 15mg
Week 21 on tirzepatide is the first injection at the 15mg maximum dose. Side effects can return, appetite goes near-silent, and the loss curve gets its final boost.
Read guidearrow_forwardWeek 22 on Semaglutide: Building Habits at Target Dose
Week 22 is deep in the 2.4mg maintenance phase. Habits are doing more of the work than novelty. Here is what to focus on at this stage.
Read guidearrow_forwardWeek 22 on Tirzepatide: First Full Week at 15mg
Week 22 on tirzepatide is the first settled week at the maximum 15mg dose. Titration noise is gone, appetite is near-total, and the trend continues at a sustainable slope.
Read guidearrow_forwardWeek 23 on Semaglutide: Approaching the Half-Year Mark
Week 23 is the last week before the six-month milestone on semaglutide. A natural time to prepare data and questions for the half-year review.
Read guidearrow_forwardWeek 23 on Tirzepatide: Approaching the Half-Year Mark
Week 23 on tirzepatide is the third dose at 15mg and the last week before the six-month milestone. Time to prepare the data and read the half-year picture.
Read guidearrow_forwardWeek 24 on Semaglutide: The Six-Month Milestone
Week 24 marks six months on semaglutide. STEP trial data shows ~10% mean body-weight loss at this point. Here is how to review and plan ahead.
Read guidearrow_forwardWeek 24 on Tirzepatide: The Six-Month Milestone
Week 24 on tirzepatide marks six months. SURMOUNT-1 puts cumulative loss near 20% on 15mg at this point. Time to review the half-year and plan ahead.
Read guidearrow_forwardeventMonth markers (Month 3 - 12) (8)
Three-month checkpoints from month three through year one.
Month 12 on Semaglutide: One Year In
One year on semaglutide. STEP 1 reports ~14.9% mean weight loss at 68 weeks, close to plateau. Time to review labs, dose, and the long-term plan.
Read guidearrow_forwardMonth 12 on Tirzepatide: One Year of Treatment Reviewed
One year on tirzepatide. SURMOUNT-1 reports up to ~20.9% mean weight loss at 72 weeks on 15mg. Review labs, dose, lean mass, and the long-term plan.
Read guidearrow_forwardMonth 3 on Semaglutide: What 12 Weeks of Treatment Looks Like
Month 3 on semaglutide is the standard checkpoint. STEP trial data shows ~6% cumulative loss, the 1.0mg dose is settling, and the next titration is on deck.
Read guidearrow_forwardMonth 3 on Tirzepatide: The First Real Milestone
Month 3 on tirzepatide is the standard checkpoint. SURMOUNT-1 shows ~10% cumulative loss by 12 weeks on the higher dose. Time to review and plan.
Read guidearrow_forwardMonth 6 on Semaglutide: The Halfway Mark of a Year
Month 6 on semaglutide marks the halfway point. STEP 1 shows ~10% cumulative loss, the dose is approaching maintenance, and the trajectory is set.
Read guidearrow_forwardMonth 6 on Tirzepatide: Halfway Through the First Year
Month 6 on tirzepatide marks halfway. SURMOUNT-1 shows ~15% cumulative loss on the higher dose. Dose at 10mg, side effects routine, plateaus possible.
Read guidearrow_forwardMonth 9 on Semaglutide: Approaching Maintenance
Month 9 on semaglutide is where the curve begins to flatten. STEP 1 data shows ~13% cumulative loss, and the conversation shifts toward maintenance.
Read guidearrow_forwardMonth 9 on Tirzepatide: Where the Curve Levels Out
Month 9 on tirzepatide is where the steep loss curve begins to flatten. SURMOUNT-1 shows ~18% cumulative loss on the higher dose at this stage.
Read guidearrow_forward